Adobe Lightroom totally rocks. I used this for some recent flickr posts that involved more than average cleanup and it really is a complete pleasure to use. I did, just for the sake of comparison, throw some of the same work at a trial copy of Aperture 1.5 and this was not a particular happy experience (possibly because I am not in posession of a video card based on Quantum Computing or whatever it is that is needed to make this app perform well.) Well done, Adobe. My investigation here was prompted by Ars' review which seems to be spot on, based on my experience so far.
I'm currently using Camino as my main Mac browser. I've (probably unfairly) ignored Camino due to it's somewhat homely default appearance (I am that shallow,) but then I found CaminIcon, which let me fix that (Jon Hicks' theme + the Omni tabs.) Pluses, Firefox's AJAX/js performance without the XUL-related UI strangeness. Minuses, no bookmark sync, no plugins, Firefox's (slow) memory leaks.
My search for the perfect pointing device continues with the Kensington Expert Mouse. This isn't exactly an attractive device but it works really well. Unlike thumb-driven trackballs which seem to require you to relearn eye-hand coordination, the action to drive it is very like driving a tiny but very smooth & precise regular mouse. The scroll ring is also very intuitive (imagine an iPod scroll wheel on a mouse) but also sounds and feels quite rough - the biggest negative with this device - everything the Amazon reviews say here is true. On the plus side, having a button dedicated to click+drag means you can use the ball like an analog control for sliders (for example, in Lightroom) - very, very useful.